Septopal

Polymethylmethacrylate (PMMA) chains and minichains loaded with gentamicin sulphate. The basic measure in osteomyelitis and osteitis surgical treatment is the radical debridement. The essential complementary measure of surgery is the local implantation of gentamicin PMMA beads, insuring a high infection healing rate and a low infection recurrence rate on a long term survey.

Features

High local antibiotic concentration, precisely where the infection takes place
Broad antibacterial spectrum
Effective on bacterial species which are known to be resistant against systemic antibiotic concentrations
No systemic side-effects for the patients

Current papers:

(1) Walenkamp G. „A clinical, pharmacokinetic and toxicological study". Drukkerij Cliteur Amsterdam (1983)

(2) Reconstruction surgery and traumatology, editor H. Eberle „Gentamicin PMMA chains in bone and soft-tissues infections"

(3) Jenny G and al. „Les billes de ciment acrylique à la gentamicine dans le traitement de l'infection de l'appareil locomoteur". Orthop. Traumatologie (1994); 4: 101-104

(4) Dingeldein E and al. Biomaterials (1980); 315

(5) Klemm K. Clin. Orthop. (1993); 63.

(6) Schmidt J and al. „Is instillation drainage for the treatment of infected joints, bones and soft-tissues still up to date?" Arch. Orthop. Trauma. Surgery (1996); 115(3-4): 149-52

(7) Zimmer K. „Use of miniSeptopal in trauma surgery of the hand, experimental and clinical studies". Polim-Med (1996); 26(1-2): 3-57

(8) Blaha JD and al. „Comparison of the clinical efficacy and tolerance of gentamicin PMMA beads on surgical wire vs combined and systemic therapy for osteomyelitis". Clin. Orthop. (1993) Oct; 295: 8-12

(9) Walenkamp G and al. „Osteomyelitis treatment with gentamicin PMMA beads. 100 patients followed for 1-12 years". Acta. Orthop. Scand. (1998) Oct; 69(5): 518-22

For further information about the products, health care professionals should contact their Biomet Europe representative or local office. Patients with questions about products are advised to contact their local surgeon.